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c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3(+) CD4 Regulatory T Cells
The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(−)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κ...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204987/ https://ncbi.nlm.nih.gov/pubmed/22066012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026851 |
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