c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(-)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κ...

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Bibliografische gegevens
Hoofdauteurs: George Grigoriadis, Ajithkumar Vasanthakumar, Ashish Banerjee, Raelene Grumont, Sarah Overall, Paul Gleeson, Frances Shannon, Steve Gerondakis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science (PLoS) 2011-01-01
Reeks:PLoS ONE
Online toegang:http://europepmc.org/articles/PMC3204987?pdf=render
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