Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor

Achieving high-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important clinical impact in addition to enabling elucidation of their regulation. Here, we couple the ability of engineered NUP98-HOXA10hd expression to stimulate > 1000-fold net expansions of murine HSCs in...

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Hauptverfasser: Sekulovic, Sanja, Gasparetto, Maura, Lecault, Véronique, Hoesli, Corinne A., Kent, David G., Rosten, Patty, Wan, Adrian, Brookes, Christy, Hansen, Carl L., Piret, James M., Smith, Clayton, Eaves, Connie J., Humphries, R. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Hematopoiesis and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204908/
https://ncbi.nlm.nih.gov/pubmed/21865344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-350066
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