DELINEATING THE KEY REGIONS AND FUNCTIONS OF NUP98 CONTRIBUTING TO THE LEUKEMOGENIC ACTIVITY OF NUP98-HOX FUSIONS

To determine the contribution of the common N-terminal truncation of NUP98 in NUP98-translocations resulting in acute myeloid leukemia, we have conducted a structure-function analysis of NUP98 in the context of NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion that significantly enhances the self-...

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Autores principales: Yung, Eric, Sekulovic, Sanja, Argiropoulos, Bob, Lai, Courteney K., Leung, Malina, Vollett, Sarah, Chang, Vicky Chi-Dan, Wan, Adrian, Wong, Sandy, Humphries, R. Keith
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4072657/
https://ncbi.nlm.nih.gov/pubmed/21130494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.10.006
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