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DELINEATING THE KEY REGIONS AND FUNCTIONS OF NUP98 CONTRIBUTING TO THE LEUKEMOGENIC ACTIVITY OF NUP98-HOX FUSIONS
To determine the contribution of the common N-terminal truncation of NUP98 in NUP98-translocations resulting in acute myeloid leukemia, we have conducted a structure-function analysis of NUP98 in the context of NUP98-HOXA10HD, a novel, canonical NUP98-Hox fusion that significantly enhances the self-...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4072657/ https://ncbi.nlm.nih.gov/pubmed/21130494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2010.10.006 |
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