Biomolecular condensation of NUP98 fusion proteins drives leukemogenic gene expression

NUP98 fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98 fusion proteins share an intrinsically disordered region (IDR) in the NUP98 N terminus, featuring repeats of phenylalanine-glycine (FG), and C-terminal fusion partners often function in gene control. We investigated whe...

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Publicado en:Nat Struct Mol Biol
Main Authors: Terlecki-Zaniewicz, Stefan, Humer, Theresa, Eder, Thomas, Schmoellerl, Johannes, Heyes, Elizabeth, Manhart, Gabriele, Kuchynka, Natalie, Parapatics, Katja, Liberante, Fabio G., Müller, André C., Tomazou, Eleni M., Grebien, Florian
Formato: Artigo
Idioma:Inglês
Publicado: 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116736/
https://ncbi.nlm.nih.gov/pubmed/33479542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-00550-w
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