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Candidate Genes for Expansion and Transformation of Hematopoietic Stem Cells by NUP98-HOX Fusion Genes

BACKGROUND: Hox genes are implicated in hematopoietic stem cell (HSC) regulation as well as in leukemia development through translocation with the nucleoporin gene NUP98. Interestingly, an engineered NUP98-HOXA10 (NA10) fusion can induce a several hundred-fold expansion of HSCs in vitro and NA10 and...

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Bibliografische gegevens
Hoofdauteurs: Palmqvist, Lars, Pineault, Nicolas, Wasslavik, Carina, Humphries, R. Keith
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1942085/
https://ncbi.nlm.nih.gov/pubmed/17712416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000768
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