Prolonged self-renewal activity unmasks telomerase control of telomere homeostasis and function of mouse hematopoietic stem cells

Strategies for expanding hematopoietic stem cells (HSCs) could have significant utility for transplantation-based therapies. However, deleterious consequences of such manipulations remain unknown. Here we examined the impact of HSC self-renewal divisions in vitro and in vivo on their subsequent rege...

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Main Authors: Sekulovic, Sanja, Gylfadottir, Vala, Vulto, Irma, Gasparetto, Maura, Even, Yasmine, Brookes, Christy, Smith, Clayton, Eaves, Connie J., Lansdorp, Peter M., Rossi, Fabio M., Humphries, R. Keith
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158711/
https://ncbi.nlm.nih.gov/pubmed/21730353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-319632
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