Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

Therapies inhibiting receptor tyrosine kinases (RTKs) are effective against some human cancers when they lead to simultaneous downregulation of PI3K/AKT and MEK/ERK signaling. However, mutant KRAS has the capacity to directly activate ERK and PI3K signaling, and this is thought to underlie the resis...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Ebi, Hiromichi, Corcoran, Ryan B., Singh, Anurag, Chen, Zhao, Song, Youngchul, Lifshits, Eugene, Ryan, David P., Meyerhardt, Jeffrey A., Benes, Cyril, Settleman, Jeffrey, Wong, Kwok-Kin, Cantley, Lewis C., Engelman, Jeffrey A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204842/
https://ncbi.nlm.nih.gov/pubmed/21985784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57909
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items