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Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair

Double-strand breaks (DSBs), arising from exposure to exogenous clastogens or as a by-product of endogenous cellular metabolism, pose grave threats to genome integrity. DSBs can sever whole chromosomes, leading to chromosomal instability, a hallmark of cancer. Healing broken DNA takes time, and it i...

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Bibliografiske detaljer
Main Authors: Langerak, Petra, Russell, Paul
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203453/
https://ncbi.nlm.nih.gov/pubmed/22084383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0070
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