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Regulatory networks integrating cell cycle control with DNA damage checkpoints and double-strand break repair
Double-strand breaks (DSBs), arising from exposure to exogenous clastogens or as a by-product of endogenous cellular metabolism, pose grave threats to genome integrity. DSBs can sever whole chromosomes, leading to chromosomal instability, a hallmark of cancer. Healing broken DNA takes time, and it i...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203453/ https://ncbi.nlm.nih.gov/pubmed/22084383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2011.0070 |
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