Impact of the Nature and Size of the Polymeric Backbone on the Ability of Heterobifunctional Ligands to Mediate Shiga Toxin and Serum Amyloid P Component Ternary Complex Formation

Inhibition of AB(5)-type bacterial toxins can be achieved by heterobifunctional ligands (BAITs) that mediate assembly of supramolecular complexes involving the toxin’s pentameric cell membrane-binding subunit and an endogenous protein, serum amyloid P component, of the innate immune system. Effectiv...

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Main Authors: Kitov, Pavel I., Paszkiewicz, Eugenia, Sadowska, Joanna M., Deng, Zhicheng, Ahmed, Marya, Narain, Ravin, Griener, Thomas P., Mulvey, George L., Armstrong, Glen D., Bundle, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202879/
https://ncbi.nlm.nih.gov/pubmed/22069757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins3091065
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