In vivo supramolecular templating enhances the activity of multivalent ligands: A potential therapeutic against the Escherichia coli O157 AB(5) toxins

We demonstrate that interactions between multimeric receptors and multivalent ligands are dramatically enhanced by recruiting a complementary templating receptor such as an endogenous multimeric protein but only when individual ligands are attached to a polymer as preorganized, covalent, heterobifun...

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Hlavní autoři: Kitov, Pavel I., Mulvey, George L., Griener, Thomas P., Lipinski, Tomasz, Solomon, Dmitry, Paszkiewicz, Eugenia, Jacobson, Jared M., Sadowska, Joanna M., Suzuki, Missao, Yamamura, Ken-ichi, Armstrong, Glen D., Bundle, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573949/
https://ncbi.nlm.nih.gov/pubmed/18955695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804919105
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