Assessing ‘Radiosensitivity’ with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 Foci

BACKGROUND AND PURPOSE: DNA repair assays to identify radiosensitive patients have had limited clinical implementation due to long turn-around times or limited specificity. This study evaluates γ-H2AX Irradiation Induced Foci (IRIF) kinetics as a more rapid surrogate for the ‘gold standard’ colony s...

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Hauptverfasser: Martin, Nathan T., Nahas, Shareef A., Tunuguntla, Rashmi, Fike, Francesca, Gatti, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202034/
https://ncbi.nlm.nih.gov/pubmed/21722985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.radonc.2011.05.065
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