HLA-B27 Selects for Rare Escape Mutations that Significantly Impair Hepatitis C Virus Replication and Require Compensatory Mutations

HLA-B27 is associated with spontaneous viral clearance in hepatitis C virus (HCV) infection. Viral escape within the immunodominant HLA-B27 restricted HCV-specific CD8+ T cell epitope NS5B(2841-2849) (ARMILMTHF) has been shown to be limited by viral fitness costs as well as broad T cell cross-recogn...

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Main Authors: Neumann-Haefelin, Christoph, Oniangue-Ndza, Cesar, Kuntzen, Thomas, Schmidt, Julia, Nitschke, Katja, Sidney, John, Caillet-Saguy, Célia, Binder, Marco, Kersting, Nadine, Kemper, Michael W., Power, Karen A., Ingber, Susan, Reyor, Laura L., Hills-Evans, Kelsey, Kim, Arthur Y., Lauer, Georg M., Lohmann, Volker, Sette, Alessandro, Henn, Matthew R., Bressanelli, Stéphane, Thimme, Robert, Allen, Todd M.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201753/
https://ncbi.nlm.nih.gov/pubmed/22006856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24541
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