Protective Effect of Human Leukocyte Antigen B27 in Hepatitis C Virus Infection Requires the Presence of a Genotype-Specific Immunodominant CD8+ T-Cell Epitope

Human leukocyte antigen B27 (HLA-B27) is associated with protection in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. This protective role is linked to single immunodominant HLA-B27-restricted CD8+ T-cell epitopes in both infections. In order to define the relative contrib...

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Publicado no:Hepatology
Main Authors: Neumann-Haefelin, Christoph, Timm, Jörg, Schmidt, Julia, Kersting, Nadine, Fitzmaurice, Karen, Oniangue-Ndza, Cesar, Kemper, Michael N., Humphreys, Isla, McKiernan, Susan, Kelleher, Dermot, Lohmann, Volker, Bowness, Paul, Huzly, Daniela, Rosen, Hugo R., Kim, Arthur Y., Lauer, Georg M., Allen, Todd M., Barnes, Eleanor, Roggendorf, Michael, Blum, Hubert E., Thimme, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396188/
https://ncbi.nlm.nih.gov/pubmed/20034048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23275
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