Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

Failure of the adaptive immune response to control infection with the hepatitis C virus (HCV) can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune pressure is an important factor in the evolution of the nonstructural proteins in HCV. The aim of thi...

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Detalhes bibliográficos
Main Authors: Neumann-Haefelin, Christoph, Frick, David N., Wang, Jing Jing, Pybus, Oliver G., Salloum, Shadi, Narula, Gagandeep S., Eckart, Anna, Biezynski, Andrea, Eiermann, Thomas, Klenerman, Paul, Viazov, Sergei, Roggendorf, Michael, Thimme, Robert, Reiser, Markus, Timm, Jörg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268453/
https://ncbi.nlm.nih.gov/pubmed/18216107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01700-07
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