Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism for T-cell failure. H...

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Main Authors: Salloum, Shadi, Oniangue-Ndza, Cesar, Neumann-Haefelin, Christoph, Hudson, Laura, Giugliano, Silvia, aus dem Siepen, Marc, Nattermann, Jacob, Spengler, Ulrich, Lauer, Georg M., Wiese, Manfred, Klenerman, Paul, Bright, Helen, Scherbaum, Norbert, Thimme, Robert, Roggendorf, Michael, Viazov, Sergei, Timm, Joerg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583685/
https://ncbi.nlm.nih.gov/pubmed/18815309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00997-08
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