Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes during acute HCV infection has been well documented and is one possible mechanism for T-cell failure. H...

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Autors principals: Salloum, Shadi, Oniangue-Ndza, Cesar, Neumann-Haefelin, Christoph, Hudson, Laura, Giugliano, Silvia, aus dem Siepen, Marc, Nattermann, Jacob, Spengler, Ulrich, Lauer, Georg M., Wiese, Manfred, Klenerman, Paul, Bright, Helen, Scherbaum, Norbert, Thimme, Robert, Roggendorf, Michael, Viazov, Sergei, Timm, Joerg
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2008
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583685/
https://ncbi.nlm.nih.gov/pubmed/18815309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00997-08
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