HLA-B*27 subtype specificity determines targeting and viral evolution of a hepatitis C virus-specific CD8+ T-cell epitope

BACKGROUND & AIMS: HLA-B*27 is associated with spontaneous HCV genotype 1 clearance. HLA-B*27-restricted CD8+ T-cells target three NS5B epitopes. Two of these epitopes are dominantly targeted in the majority of HLA-B*27+ patients. In chronic infection, viral escape occurs consistently in these t...

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Main Authors: Nitschke, Katja, Barriga, Alejandro, Schmidt, Julia, Timm, Jörg, Viazov, Sergei, Kuntzen, Thomas, Kim, Arthur Y., Lauer, Georg M., Allen, Todd M., Gaudieri, Silvana, Rauch, Andri, Lange, Christian M., Sarrazin, Christoph, Eiermann, Thomas, Sidney, John, Sette, Alessandro, Thimme, Robert, López, Daniel, Neumann-Haefelin, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867523/
https://ncbi.nlm.nih.gov/pubmed/23978718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2013.08.009
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