The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation

BACKGROUND & AIMS: Cyclophilin-inhibitors have potent antiviral activity against Hepatitis C virus (HCV) and are promising candidates for broad-spectrum antiviral therapy. Cyclosporine A (CsA) acts immunosuppressive by blocking T cell activation and antigen presentation. Alisporivir, a non-immun...

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Detalles Bibliográficos
Publicado en:J Hepatol
Main Authors: Esser-Nobis, Katharina, Schmidt, Julia, Nitschke, Katja, Neumann-Haefelin, Christoph, Thimme, Robert, Lohmann, Volker
Formato: Artigo
Idioma:Inglês
Publicado: European Association for the Study of the Liver. Published by Elsevier B.V. 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7172366/
https://ncbi.nlm.nih.gov/pubmed/26921685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.02.027
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