Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8(+) T Cell Responses Is Linked to Naïve-Precursor Frequency

The impact of naïve-precursor frequency on human virus-specific CD8(+) T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naïve-precursor...

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Bibliografski detalji
Glavni autori: Schmidt, Julia, Neumann-Haefelin, Christoph, Altay, Tayibe, Gostick, Emma, Price, David A., Lohmann, Volker, Blum, Hubert E., Thimme, Robert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Pathogenesis and Immunity
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126217/
https://ncbi.nlm.nih.gov/pubmed/21367907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00093-11
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