Differential Activity of NADPH-Producing Dehydrogenases Renders Rodents Unsuitable Models to Study IDH1(R132) Mutation Effects in Human Glioblastoma

The somatic IDH1(R132) mutation in the isocitrate dehydrogenase 1 gene occurs in high frequency in glioma and in lower frequency in acute myeloid leukemia and thyroid cancer but not in other types of cancer. The mutation causes reduced NADPH production capacity in glioblastoma by 40% and is associat...

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Main Authors: Atai, Nadia A., Renkema-Mills, Nynke A., Bosman, Joost, Schmidt, Nadja, Rijkeboer, Denise, Tigchelaar, Wikky, Bosch, Klazien S., Troost, Dirk, Jonker, Ard, Bleeker, Fonnet E., Miletic, Hrvoje, Bjerkvig, Rolf, De Witt Hamer, Philip C., Van Noorden, Cornelis J. F.
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201175/
https://ncbi.nlm.nih.gov/pubmed/21527585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155411400606
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