The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone

BACKGROUND: Genetic and epigenetic profiling of glioblastomas has provided a comprehensive list of altered cancer genes of which only O(6)-methylguanine-methyltransferase (MGMT) methylation is used thus far as a predictive marker in a clinical setting. We investigated the prognostic significance of...

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Detalhes bibliográficos
Main Authors: Molenaar, Remco J., Verbaan, Dagmar, Lamba, Simona, Zanon, Carlo, Jeuken, Judith W.M., Boots-Sprenger, Sandra H.E., Wesseling, Pieter, Hulsebos, Theo J.M., Troost, Dirk, van Tilborg, Angela A., Leenstra, Sieger, Vandertop, W. Peter, Bardelli, Alberto, van Noorden, Cornelis J.F., Bleeker, Fonnet E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136888/
https://ncbi.nlm.nih.gov/pubmed/24510240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou005
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