A Kinetic Model Linking Protein Conformational Motions, Interflavin Electron Transfer, and Electron Flux through a Dual-Flavin Enzyme: Simulating the reductase activity of the endothelial and neuronal NO Synthase flavoprotein domains

Lignende værker

• Distinct Conformational Behaviors of Four Mammalian Dual-Flavin Reductases (Cytochrome P450 Reductase, Methionine Synthase Reductase, Neuronal Nitric Oxide Synthase, Endothelial Nitric Oxide Synthase) Determine their Unique Catalytic Profiles
  af: Haque, Mohammad Mahfuzul, et al.
  Udgivet: (2014)
• Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis
  af: Dai, Yue, et al.
  Udgivet: (2017)
• Structural and mechanistic aspects of flavoproteins: electron transfer through the nitric oxide synthase flavoprotein domain
  af: Stuehr, Dennis J., et al.
  Udgivet: (2009)
• Lys(842) in Neuronal Nitric-oxide Synthase Enables the Autoinhibitory Insert to Antagonize Calmodulin Binding, Increase FMN Shielding, and Suppress Interflavin Electron Transfer
  af: Guan, Zhi-Wen, et al.
  Udgivet: (2010)
• Charge Pairing Interactions Control the Conformational Setpoint and Motions of the FMN Domain in Neuronal Nitric Oxide Synthase
  af: Haque, Mohammad Mahfuzul, et al.
  Udgivet: (2013)