Lys(842) in Neuronal Nitric-oxide Synthase Enables the Autoinhibitory Insert to Antagonize Calmodulin Binding, Increase FMN Shielding, and Suppress Interflavin Electron Transfer

Neuronal nitric-oxide synthase (nNOS) contains a unique autoinhibitory insert (AI) in its FMN subdomain that represses nNOS reductase activities and controls the calcium sensitivity of calmodulin (CaM) binding to nNOS. How the AI does this is unclear. A conserved charged residue (Lys(842)) lies with...

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Main Authors: Guan, Zhi-Wen, Haque, Mohammad Mahfuzul, Wei, Chin-Chuan, Garcin, Elsa D., Getzoff, Elizabeth D., Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzyme Catalysis and Regulation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823414/
https://ncbi.nlm.nih.gov/pubmed/19948738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.000810
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