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A Kinetic Model Linking Protein Conformational Motions, Interflavin Electron Transfer, and Electron Flux through a Dual-Flavin Enzyme: Simulating the reductase activity of the endothelial and neuronal NO Synthase flavoprotein domains

NADPH-dependent dual-flavin enzymes provide electrons in many redox reactions, but what regulates their electron flux is unclear. We recently proposed a four-state kinetic model that links the electron flux through a dual-flavin enzyme to its rates of interflavin electron transfer and FMN domain con...

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Detalles Bibliográficos
Main Authors: Haque, Mohammad Mahfuzul, Kenney, Claire, Tejero, Jesús, Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3200465/
https://ncbi.nlm.nih.gov/pubmed/21848659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2011.08310.x
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