Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor

Biologic tumor necrosis factor (TNF)-α inhibitors do not cross the blood-brain barrier (BBB). A BBB-penetrating TNF-α inhibitor was engineered by fusion of the extracellular domain of the type II human TNF receptor (TNFR) to the carboxyl terminus of the heavy chain of a mouse/rat chimeric monoclonal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhou, Qing-Hui, Sumbria, Rachita, Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Boado, Ruben J., Pardridge, William M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Pharmacology and Experimental Therapeutics 2011
Gaiak:
Neuropharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3199996/
https://ncbi.nlm.nih.gov/pubmed/21831964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185876
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