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Neuroprotection with a Brain-Penetrating Biologic Tumor Necrosis Factor Inhibitor
Biologic tumor necrosis factor (TNF)-α inhibitors do not cross the blood-brain barrier (BBB). A BBB-penetrating TNF-α inhibitor was engineered by fusion of the extracellular domain of the type II human TNF receptor (TNFR) to the carboxyl terminus of the heavy chain of a mouse/rat chimeric monoclonal...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199996/ https://ncbi.nlm.nih.gov/pubmed/21831964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.185876 |
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