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Brain-Penetrating Tumor Necrosis Factor Decoy Receptor in the Mouse
Biologic tumor necrosis factor inhibitors (TNFIs) include TNF decoy receptors (TNFRs). TNFα plays a pathologic role in both acute and chronic brain disease. However, biologic TNFIs cannot be developed as brain therapeutics because these large molecule drugs do not cross the blood-brain barrier (BBB)...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014268/ https://ncbi.nlm.nih.gov/pubmed/20884844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.036012 |
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