Intravenous treatment of experimental Parkinson’s disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier

Glial derived neurotrophic factor (GDNF) is a trophic factor for the nigra-striatal tract in experimental Parkinson’s disease (PD). The neurotrophin must be administered by intra-cerebral injection, because GDNF does not cross the blood-brain barrier (BBB). In the present study, GDNF was re-engineer...

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Bibliographic Details
Main Authors: Fu, Ailing, Zhou, Qing-Hui, Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Boado, Ruben J., Pardridge, William M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2926206/
https://ncbi.nlm.nih.gov/pubmed/20599807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2010.06.059
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