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Pharmacokinetics and Brain Uptake of an IgG-TNF Decoy Receptor Fusion Protein Following Intravenous, Intraperitoneal and Subcutaneous Administration in the Mouse

Tumor necrosis factor (TNF)-α is a proinflammatory cytokine active in the brain. Etanercept, the TNF decoy receptor (TNFR), does not cross the blood-brain barrier (BBB). The TNFR was re-engineered for BBB penetration as a fusion protein with a chimeric monoclonal antibody (MAb) against the mouse tra...

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書誌詳細
主要な著者: Sumbria, Rachita K., Zhou, Qing-Hui, Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Boado, Ruben J., Pardridge, William M.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3615110/
https://ncbi.nlm.nih.gov/pubmed/23410508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400004a
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