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Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein
Tumor necrosis factor (TNF)-α is produced in brain in response to acute cerebral ischemia, and promotes neuronal apoptosis. Biologic TNF inhibitors (TNFIs), such as the etanercept, cannot be developed as new stroke treatments because these large molecule drugs do not cross the blood–brain barrier (B...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463885/ https://ncbi.nlm.nih.gov/pubmed/22714051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2012.97 |
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