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Pharmacokinetics and Brain Uptake in the Rhesus Monkey of a Fusion Protein of Arylsulfatase A and a Monoclonal Antibody Against the Human Insulin Receptor

Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder of the brain caused by mutations in the gene encoding the lysosomal sulfatase, arylsulfatase A (ASA). It is not possible to treat the brain in MLD with recombinant ASA, because the enzyme does not cross the blood-brain barrier (BBB)....

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Détails bibliographiques
Auteurs principaux: Boado, Ruben J., Lu, Jeff Zhiqiang, Hui, Eric K.-W., Sumbria, Rachita K., Pardridge, William M.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919501/
https://ncbi.nlm.nih.gov/pubmed/23192358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.24795
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