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Glycemic Control and Chronic Dosing of Rhesus Monkeys with a Fusion Protein of Iduronidase and a Monoclonal Antibody Against the Human Insulin Receptor

Hurler's syndrome, or mucopolysaccharidosis type I, is a lysosomal storage disorder caused by mutations in the gene encoding the lysosomal enzyme iduronidase (IDUA). The disease affects both peripheral tissues and the central nervous system (CNS). Recombinant IDUA treatment does not affect the...

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Bibliografski detalji
Glavni autori: Boado, Ruben J., Hui, Eric Ka-Wai, Lu, Jeff Zhiqiang, Pardridge, William M.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463822/
https://ncbi.nlm.nih.gov/pubmed/22822036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.046375
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