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Expression in CHO Cells and Pharmacokinetics and Brain Uptake in the Rhesus Monkey of an IgG-Iduronate-2-Sulfatase Fusion Protein
Sulfatases are potential therapeutic biopharmaceuticals, as mutations in sulfatase genes leads to inherited disease. Mucopolysaccharidosis (MPS) Type II is caused by mutations in the lysosomal enzyme, iduronate 2-sulfatase (IDS). MPS-II affects the brain and enzyme replacement therapy is ineffective...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117053/ https://ncbi.nlm.nih.gov/pubmed/21351076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.23118 |
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