Thiocyanate and hydroxyl ions inactivate the scrapie agent.

To probe the macromolecular structure of the scrapie agent and explore conditions for monomerization, the stability of the agent in low concentrations of inorganic ions was determined. A reduction by a factor of 10(5) in scrapie titer was found on exposure of the agent to 1 M KSCN or 0.3 M NaOH. In...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Prusiner, S B, Groth, D F, McKinley, M P, Cochran, S P, Bowman, K A, Kasper, K C
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1981
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319842/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6794034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4606
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