Thiocyanate and hydroxyl ions inactivate the scrapie agent.

To probe the macromolecular structure of the scrapie agent and explore conditions for monomerization, the stability of the agent in low concentrations of inorganic ions was determined. A reduction by a factor of 10(5) in scrapie titer was found on exposure of the agent to 1 M KSCN or 0.3 M NaOH. In...

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Detaylı Bibliyografya
Asıl Yazarlar: Prusiner, S B, Groth, D F, McKinley, M P, Cochran, S P, Bowman, K A, Kasper, K C
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1981
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC319842/
https://ncbi.nlm.nih.gov/pubmed/6794034
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