Thiocyanate and hydroxyl ions inactivate the scrapie agent.

To probe the macromolecular structure of the scrapie agent and explore conditions for monomerization, the stability of the agent in low concentrations of inorganic ions was determined. A reduction by a factor of 10(5) in scrapie titer was found on exposure of the agent to 1 M KSCN or 0.3 M NaOH. In...

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Main Authors: Prusiner, S B, Groth, D F, McKinley, M P, Cochran, S P, Bowman, K A, Kasper, K C
Format: Artigo
Jezik:Inglês
Izdano: 1981
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC319842/
https://ncbi.nlm.nih.gov/pubmed/6794034
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