Thiocyanate and hydroxyl ions inactivate the scrapie agent.

To probe the macromolecular structure of the scrapie agent and explore conditions for monomerization, the stability of the agent in low concentrations of inorganic ions was determined. A reduction by a factor of 10(5) in scrapie titer was found on exposure of the agent to 1 M KSCN or 0.3 M NaOH. In...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Prusiner, S B, Groth, D F, McKinley, M P, Cochran, S P, Bowman, K A, Kasper, K C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1981
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC319842/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6794034/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.78.7.4606
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