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Enhancement of antibody class switch recombination by the cumulative activity of four separate elements()

Class switch recombination of antibody isotype is mediated by a recombinational DNA deletion event, and must be robustly upregulated during antigen-driven differentiation of B cells. The enhancer region 3′ of the Cα gene is important for the upregulation of switch recombination. Using a transgene of...

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Autori principali: Dunnick, Wesley A., Shi, Jian, Zerbato, Jennifer M., Fontaine, Clinton A., Collins, John T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197901/
https://ncbi.nlm.nih.gov/pubmed/21949022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101808
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