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Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region
Both class switch recombination (CSR) and somatic hypermutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminase (AID), and must be up-regulated during antigen-dependent differentiation of B lymphocytes. To test the role of the heavy chain 3′ enhancers in...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2806627/ https://ncbi.nlm.nih.gov/pubmed/19887393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091280 |
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