Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

Both class switch recombination (CSR) and somatic hypermutation (SHM) require transcription and the trans-acting factor activation-induced cytidine deaminase (AID), and must be up-regulated during antigen-dependent differentiation of B lymphocytes. To test the role of the heavy chain 3′ enhancers in...

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Detalhes bibliográficos
Main Authors: Dunnick, Wesley A., Collins, John T., Shi, Jian, Westfield, Gerwin, Fontaine, Clinton, Hakimpour, Paul, Papavasiliou, F. Nina
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806627/
https://ncbi.nlm.nih.gov/pubmed/19887393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091280
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