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Transgenes of the Mouse Immunoglobulin Heavy Chain Locus, Lacking Distal Elements in the 3′ Regulatory Region, Are Impaired for Class Switch Recombination

The immunoglobulin heavy (H) chain class switch is mediated by a deletional recombination event between µ and γ, α, or ε constant region genes. This recombination event is upregulated during immune responses by a regulatory region that lies 3′ of the constant region genes. We study switch recombinat...

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書誌詳細
主要な著者: Dunnick, Wesley A., Shi, Jian, Fontaine, Clinton, Collins, John T.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568100/
https://ncbi.nlm.nih.gov/pubmed/23409061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055842
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