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FRNK Inhibits Vascular Smooth Muscle Cell Invasion by Focal Adhesion Targeting, Tyrosine-168 Phosphorylation, and Competition for p130(Cas) Binding

OBJECTIVES: FRNK, the C-terminal domain of focal adhesion kinase (FAK), is a tyrosine-phosphorylated, vascular smooth muscle cell (VSMC)-specific inhibitor of cell migration. FRNK inhibits both FAK and PYK2 in cultured VSMCs, and both kinases may be involved in VSMC invasion during vascular remodeli...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Koshman, Yevgeniya E., Chu, Miensheng, Engman, Steven J., Kim, Taehoon, Iyengar, Rekha, Robia, Seth L., Samarel, Allen M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197899/
https://ncbi.nlm.nih.gov/pubmed/21852560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.235549
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