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FRNK Inhibits Vascular Smooth Muscle Cell Invasion by Focal Adhesion Targeting, Tyrosine-168 Phosphorylation, and Competition for p130(Cas) Binding
OBJECTIVES: FRNK, the C-terminal domain of focal adhesion kinase (FAK), is a tyrosine-phosphorylated, vascular smooth muscle cell (VSMC)-specific inhibitor of cell migration. FRNK inhibits both FAK and PYK2 in cultured VSMCs, and both kinases may be involved in VSMC invasion during vascular remodeli...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197899/ https://ncbi.nlm.nih.gov/pubmed/21852560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.235549 |
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