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Ligand Discovery from a Dopamine D(3) Receptor Homology Model and Crystal Structure

G-Protein coupled receptors (GPCRs) are intensely studied as drug targets and for their role in signaling. With the determination of the first crystal structures, interest in structure-based ligand discovery has increased. Unfortunately, most GPCRs lack experimental structures. The determination of...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Carlsson, Jens, Coleman, Ryan G., Setola, Vincent, Irwin, John J., Fan, Hao, Schlessinger, Avner, Sali, Andrej, Roth, Bryan L., Shoichet, Brian K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3197762/
https://ncbi.nlm.nih.gov/pubmed/21926995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.662
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