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The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors
Unc13/Munc13s play a crucial function in neurotransmitter release through their MUN domain, which mediates the transition from the syntaxin-1/Munc18-1 complex to the SNARE complex. The MUN domain was suggested to be related to tethering factors, but no MUN-domain structure is available to experiment...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3197213/ https://ncbi.nlm.nih.gov/pubmed/22000513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.07.012 |
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