Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

C (2) domains are well characterized as Ca (2+)/phospholipid-binding modules, but little is known about how they mediate protein–protein interactions. In neurons, a Munc13–1 C (2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show...

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Main Authors: Lu, Jun, Machius, Mischa, Dulubova, Irina, Dai, Han, Südhof, Thomas C, Tomchick, Diana R, Rizo, Josep
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2006
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472246/
https://ncbi.nlm.nih.gov/pubmed/16732694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040192
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