Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

The levels of kynurenic acid (KYNA), an astrocyte-derived metabolite of the branched kynurenine pathway (KP) of tryptophan degradation and antagonist of α7 nicotinic acetylcholine and N-methyl-D-aspartate receptors, are elevated in the prefrontal cortex (PFC) of individuals with schizophrenia (SZ)....

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Autors principals: Sathyasaikumar, Korrapati V., Stachowski, Erin K., Wonodi, Ikwunga, Roberts, Rosalinda C., Rassoulpour, Arash, McMahon, Robert P., Schwarcz, Robert
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Regular Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196941/
https://ncbi.nlm.nih.gov/pubmed/21036897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/schbul/sbq112
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