Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals

BACKGROUND: Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number of major psychiatric diseases, including depression. Immune activation stimulates the conversion of the amino acid tryptophan to kynurenine, leading to the formation of neuroactive met...

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Detalhes bibliográficos
Publicado no:J Psychiatry Neurosci
Main Authors: Clark, Sarah M., Pocivavsek, Ana, Nicholson, James D., Notarangelo, Francesca M., Langenberg, Patricia, McMahon, Robert P., Kleinman, Joel E., Hyde, Thomas M., Stiller, John, Postolache, Teodor T., Schwarcz, Robert, Tonelli, Leonardo H.
Formato: Artigo
Idioma:Inglês
Publicado em: Joule Inc. 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082509/
https://ncbi.nlm.nih.gov/pubmed/27070351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150226
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