Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals

BACKGROUND: Neuroinflammatory processes are increasingly believed to participate in the pathophysiology of a number of major psychiatric diseases, including depression. Immune activation stimulates the conversion of the amino acid tryptophan to kynurenine, leading to the formation of neuroactive met...

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Bibliographic Details
Published in:J Psychiatry Neurosci
Main Authors: Clark, Sarah M., Pocivavsek, Ana, Nicholson, James D., Notarangelo, Francesca M., Langenberg, Patricia, McMahon, Robert P., Kleinman, Joel E., Hyde, Thomas M., Stiller, John, Postolache, Teodor T., Schwarcz, Robert, Tonelli, Leonardo H.
Format: Artigo
Language:Inglês
Published: Joule Inc. 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082509/
https://ncbi.nlm.nih.gov/pubmed/27070351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150226
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