Dysregulation of kynurenine metabolism is related to proinflammatory cytokines, attention, and prefrontal cortex volume in schizophrenia

The kynurenine pathway (KP) of tryptophan (TRP) catabolism links immune system activation with neurotransmitter signaling. The KP metabolite kynurenic acid (KYNA) is increased in the brains of people with schizophrenia. We tested the extent to which: (1) brain KP enzyme mRNAs, (2) brain KP metabolit...

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Udgivet i:Mol Psychiatry
Main Authors: Kindler, Jochen, Lim, Chai K., Weickert, Cynthia Shannon, Boerrigter, Danny, Galletly, Cherrie, Liu, Dennis, Jacobs, Kelly R., Balzan, Ryan, Bruggemann, Jason, O’Donnell, Maryanne, Lenroot, Rhoshel, Guillemin, Gilles J., Weickert, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577855/
https://ncbi.nlm.nih.gov/pubmed/30940904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0401-9
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